Patricia Oteiza De Fraga

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Professor

Research:

Dr. Oteiza has two primary areas of research. The first is centered on the characterization of the effects of trace mineral deficiencies, and trace mineral toxicities, on early developmental processes. Dr. Oteiza’s second area of research is focused on the putative health benefits of flavonoids.

Education:

  • Ph.D., Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
  • M.S., Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
  • M.S., Clinical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina

Teaching:

  • ETX 104 - Environmental and Nutritional Factors in Cellular Regulation and Nutritional Toxicants

Professional Activities:

Recent Publications:

Verstraeten SV, Zago MP, MacKenzie GG, Keen CL, Oteiza PI. Influence of zinc deficiency on cell-membrane fluidity in Jurkat, 3T3 and IMR-32 cells. Biochem J. 2004 Mar 1;378(Pt 2):579-87.

Mackenzie GG, Carrasquedo F, Delfino JM, Keen CL, Fraga CG, Oteiza PI. Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells. FASEB J. 2004 Jan;18(1):167-9. Epub 2003 Nov 20.

Oteiza PI, Mackenzie GG, Verstraeten SV. Metals in neurodegeneration: involvement of oxidants and oxidant-sensitive transcription factors. Mol Aspects Med. 2004 Feb-Apr;25(1-2):103-15. Review.

Verstraeten SV, Oteiza PI, Fraga CG. Membrane effects of cocoa procyanidins in liposomes and Jurkat T cells. Biol Res. 2004;37(2):293-300.

Verstraeten, S. V., Villaverde, M. S. and Oteiza, P. I. Aluminum-mediated changes on membrane fluidity affects the activity of PI-PLC but not of PLC. Chemistry and Physics of Lipids 122:159-163 (2003)

Verstraeten, S. V., and Oteiza, P. I. Aluminum-mediated changes on membrane physical properties participate in the inhibition of polyphosphoinositides hydrolysis. Archives of Biochemistry and Biophysics 408:263-271 (2003)

Verstraeten, S. V., Keen, C. L., Schmitz, H. H., Fraga, C. G. and Oteiza, P. I. Flavan-3-ols and procyanidins protect liposomes against lipid oxidation and disruption of the bilayer structure. Free Radicals in Biology and Medicine 34: 84-92 (2003)

Verstraeten, S. V., Erlejman, A. G., Zago, M. P., and Oteiza, P. I. Aluminum selectively affects membrane physical properties in human neuroblastoma (IMR-32) cells before and after differentiation. Archives of Biochemistry and Biophysics 399: 167-173 (2002)

Actis-Goreta, L., Mackenzie, G. G., Oteiza, P. I. and Fraga, C. G. Comparative study of the antioxidant capacity of wines and other plant-derived beverages. Annals of the New York Academy of Sciences 957: 1-5 (2002)

Fraga, C. G. and Oteiza, P. I. Iron toxicity and antioxidant nutrients. Toxicology 180: 23-32 (2002)

Mackenzie, G. G., Zago, M. P., Keen, C. L. and Oteiza, P. I. Low intracellular zinc impairs the translocation of activated NF-kB to the nuclei in human neuroblastoma IMR-32 cells. Journal of Biological Chemistry 277:34610-34617 (2002)

Erlejman, A. G. and Oteiza P.I. The oxidant defense system in human neuroblastoma IMR-32 cells pre- and post- differentiation to neuronal phenotypes. Neurochemical Research 27: 1491-1498 (2002)