Rice, Robert

Department of Envionmental Toxicology
4243 Meyer Hall
Phone: 530-752-5176
Fax: 530-752-3394
Email: rhrice@ucdavis.edu




Mechanisms of action of toxic and physiological agents affecting keratinocyte growth and differentiation; biochemistry and expression of specific markers in epidermal cells and appendages; metabolic activation of toxic agents in keratinocytes.  Link to Expanded Version

Education and Experience:

  • S.B. Massachusetts Institute of Technology, Cambridge, MA, 1963-1967 (Physics)
  • Ph.D.University of California, Berkeley 1967-1972 (Molecular Biology)
  • Postdoc, Depts Biochem/Biophysics and Food Science & Technology, UC Davis, 1972-75
  • Postdoc, Dept Biology, Massachusetts Institute of Technology, Cambridge, MA, 1975-79
  • Asst/Assoc Professor, Lab Toxicology, Harvard School of Public Health, Boston, MA 1979-89
  • Professor, Dept Environmental Toxicology, University of California, Davis, CA 1990-present


  • ETX 110 - Toxic Tragedies and Their Impact on Society
  • ETX 278 - Molecular Techniques

Campus Memberships:

Recent Publications:

  • Phillips MA, Qin Q, Hu Q, Zhao B, Rice RH (2013) Arsenite suppression of BMP signaling in human keratinocytes. Toxicol Appl Pharmacol 269:290-296
  • Rice RH, Bradshaw KM, Durbin-Johnson BP, Rocke DM, Eigenheer RA, Phinney BS, Schmuth M, Gruber R (2013) Distinguishing ichthyoses by protein profiling. PLoS ONE 8(10):e75355
  • Schebb NH, Muvvala JB, Morin D, Buckpitt AR, Hammock BD, Rice RH (2014) Metabolic activation of the antibacterial agent, triclocarban, by cytochrome P450 1A1 yielding glutathione adducts. Drug Metab Disp 42:1098-1102
  • Rorke E, Gautam A, Young C, Rice R, Elias P, Crumrine D, Meyer J, Blumenberg M, Eckert R (2015) Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function. Cell Death Disease 6:e1647
  • Kumar V, Bouameur J-E, Bär J, Rice RH, Hornig‐Do H-T, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Brazel CB, Heller S, Binder H, Löffler-Wirth H, Seibel P, Magin TM (2015) A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition and activity. J Cell Biol 211:1057-1075

Links to Publications Supplementary Information:

Global alteration of gene expression in human keratinocytes by inorganic arsenic

Parallel responses of human epidermal keratinocytes to inorganic SbIII and AsIIl
Table S1. Proteomic results

Table S2. Results of next generation sequencing